Create AE Comparison Table with Risk Differences

Generate AE table with statistical comparisons (risk difference, risk ratio) between treatment groups. Essential for GBA/AMNOG safety assessments.

Usage

create_ae_comparison_table(
  data,
  adsl,
  ref_group,
  trt_var = "TRT01P",
  by = c("pt", "soc", "overall"),
  threshold = 0,
  sort_by = c("incidence", "rd", "rr"),
  conf_level = ph_default("conf_level"),
  include_nnh = TRUE,
  title = NULL,
  footnotes = character(),
  theme = "hta",
  ...
)

Arguments

data

ADAE data frame or ADaMData object containing ADaM Adverse Events dataset

adsl

ADSL data frame or ADaMData object for denominators

ref_group

Character. Reference (control) group for comparison

trt_var

Treatment variable name (default: "TRT01P")

by

Character. Grouping level: "soc", "pt", or "overall" (default: "pt")

threshold

Numeric. Minimum incidence pct in any group (default: 0)

sort_by

Character. Sort by "rd", "rr", or "incidence" (default: "incidence")

conf_level

Confidence level for intervals (default: 0.95)

include_nnh

Logical. Include NNH column (default: TRUE)

title

Table title (auto-generated if NULL)

footnotes

Character vector of footnotes (optional)

theme

Theme for table styling (default: "hta")

...

Additional arguments passed to create_clinical_table()

Value

ClinicalTable with columns for each group's n(%), RD, 95% CI, NNH, RR, p-value

Examples

if (FALSE) { # \dontrun{
# AE comparison by PT
ae_comp <- create_ae_comparison_table(
  data = adae,
  adsl = adsl,
  ref_group = "Placebo",
  by = "pt"
)

# AE comparison by SOC with 5% threshold
ae_comp_soc <- create_ae_comparison_table(
  data = adae,
  adsl = adsl,
  ref_group = "Placebo",
  by = "soc",
  threshold = 5
)
} # }